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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c11a3622e19dc395978ade3f9009b522a1c180269b06f61996ca204531198c0' 
  AND token = 'U9K+Vus2NobFQfrHuBr9SVo0/UrfDK6EqPHKmhswDiY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}