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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b3a97999d59e8864aa41648b70018d21a47f059a154a7f8849bbb08a46e52ef' 
  AND token = 'bq343yDXdQYeoaTWQ9Xz2uGfhgsV88jlEpN2Z0WJ6Eg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}