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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '445a10f24bf7cd3dbb5285e9722c9bff57b7918f2f9021ce4f3e54de53e01b36' 
  AND token = 'kF9HFHlwRVbuS1VxKfo2tuN3Bmy7PEafJVkrrpydgmw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}