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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c40726ebbd01e8d395c8c47c2ceb9657e04fb07a1fb775704fff397251016659' 
  AND token = 'mfnvr2RmAVu6Oh9565N0MjGWp+3Q8BsJ1Dw0axvw39I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}