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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '486fe4e17c24d9ce2fb8579273e6d5e003c62d455b2fa078bf16ccfd6ee5321b' 
  AND token = '0K2ErJAes2z/hY3yce65793oBgI3Act3xMftwzPFid8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}