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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12a78cb340eb8ef4476df0df6307777c23dba05ee754c2a7366a50a384961b21' 
  AND token = 'lYb/FO7kDzonOWeQyP7QxV2h4yXrB+lYXkFZFzbPqHM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}