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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '254da10dbc6d2376f5a289f76b3314149ae4e31c588e6a04f3054e9186a3edcc' 
  AND token = 'XRIwXU6m1CtVJXTw9eWMrPrMqgQ31OOytwVWSXkCjR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}