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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6270124258620d8db4244a16c1c03a621231a07eef10a6a3303f6d6b1a33eb3' 
  AND token = 'OHLPaX2XQk2Zp/7HWGGuen7VvK1t5bFTh8fc3WrdjiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}