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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '498378c533092eccb0a1ff1ae062325ec82f97f67e343e7b74016ccecb66a7e7' 
  AND token = 'tzlR+6JcxAfo+G/CeSOrjCt2HRvZgXCdl7iUicCJnZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}