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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6563b48cca9191d415f303b2015369b73b77867572752fa681dc9a18a13791be' 
  AND token = 'cwthEYbvz+S3w9y4odLlIVVHRn72bxMM4l0lgcAK4Y8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}