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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f0b3bf9a41202fa5f6978770af4ad140c5795f13ec5040be7b97d62fc1ca449' 
  AND token = 'hKjWuYWqMrZLZ1JaZDrqL/UQNILpg9Nt3L5XaMX5cT8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}