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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '481d721b7bc293eda868eb13bd97c0bcc3a263a47f3f78c5d050e780da8e309f' 
  AND token = '7KNmtsuZ27/pnqUzunaxrXSBqc8vsavRV3wYxxjQDs8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}