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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ccd3c27d72a107ca491b6da22cc3d73530b06ace29492e2ffd8ab444a611da13' 
  AND token = 'IFydtkQVR/BqhyCL8bSvYqbjV8FZDhTE2Dk3Ox8C++o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}