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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b65bde46df490f412b3f08c530f41be9f3be2794a3e86a2df67c8e63b9e53e0' 
  AND token = '+vzpJZ04vQCciqCmSaZET1bhYFV2m08AWrTAfjxmrIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}