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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b750ba7e21a3063196fef1a9f24c6b50d1ec02474a23d7c8c5c79a8a93377526' 
  AND token = 'vJIN9xJVPBAcMIBSD8XEYNGINijHPMQvnaGJ6CtWl7I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}