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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8781a01d4e0a1763314869abf951ef166fd4fef721150e5be00ff10b8e259f61' 
  AND token = 'ZUT+nT2h6wQ0g6m4K3t6h+NY5JbP40a1cmLQkyzU3Xw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}