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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '741e48bda5c7e948f712d5ad741c087aa8eedde1461016647b37cc6ea61c555a' 
  AND token = 'XgaPy2T1qhQJDhlJvkQtEjoZt+9YBZL5wdoma1xGC94=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}