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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efd1edcae512562ff283b18b2d38e3883c3a3cb0c966d810b716cdc3513c1b72' 
  AND token = 'xQRneh7S2jgsrvXqwmlnLOJCNTpT1Hxinri8NdlZ7Hk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}