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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65e80cb1925a6cb8e19c40b994e09829272054b44969f5312b4a4e628fbf415a' 
  AND token = 'f9RMU7tWwPhusejiLe4ezfnm/nEpaHykS3tWt/iAMRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}