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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10f13a9ee7294bf31da597fe68d27044d7bade8c06a021c9355421b486703412' 
  AND token = 'DV5PmBib15rp+VI8fgMUQd9CMsutzQSmH4QIK0iPBzY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}