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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a9de4e33a827a8206c6cc1acd3533e0aaa32a2c03e2e886d36d58773ab2c05d' 
  AND token = 'wF8+kSRMiiBZRtcOwM1LT3+8tjQjkHq5ixAMGFsXB3U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}