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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46f7ab7a819545163b74b4f24976467ac5621c5fdf9eb8204827530535ccf9bf' 
  AND token = 'X+wM33C/12WgjT7Wg+JAkX3MftfUuYYq9A6QQR0ySYM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}