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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10485e061f20d59a2c07e1d723ccf4064714850d59bf89e675140b43de443bc1' 
  AND token = 'YqzLbCGCTY2AEBBol+W3fYZC5yCBm7rWPKW7vK6iN5w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}