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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2483722eb6faee58fdf355b459e53b818acc7d5f1f21b493942f82da78405326' 
  AND token = 'IiSxipcyxGcsV9HUbBvv0ahMmc/SwX1f+PyDyuHDJr0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}