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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '401dc25cced592df06782580b005cb75804bd77b1842695b71141950772d8a9d' 
  AND token = 'ZgUI4WIITqU4E+HfymDH21FJgPhx0dQG8gA4BAgWTZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}