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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cfd45ff14a39b9a0d8fff6e9691682b5c0b5743692caf914329865cd15cfafe' 
  AND token = 'kUHVbVHMufcEoUx8BoOXRqX0XTHo0YkuNY2Yyh4Seoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}