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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43aa890f48e8a3ba6140b52abea5463a3cba061d736740a9af3db6b90eb5eb2a' 
  AND token = 'JBRaPyOt1Ax+QyPy0dmQL0i/FkWjg9rHAqZBwn/nH2w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}