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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64a5c730d49a6de3df2e31d23d1f12503e02e3238b2e73e67fc644de7d0ea457' 
  AND token = 'R1IvZa9Lag+4WP/dIlGLHxwJjk6XNYexHRBPOEi/+QE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}