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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f26c3c1c79c2d09e3827c37abc3a0f9dd7e39ac455f73204619e1178e377cba' 
  AND token = 'H45skXzbYWckvhFWdZXFw/l6cGplgLdjBoaymayg0PE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}