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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e257ec99793cd727e0855a7857797e3469cbf7e4ae7c8f9216059376db68787a' 
  AND token = 'RSfuHR1G6TlUPeaK+jaQSPLjH/vQiwBoXtKCoz+iqPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}