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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2277ff0f7b0fab64f8bb39f27bbb464ce0de5d2a486a86d3cb225159503a37c4' 
  AND token = 'JZw7xxHoG2hpmht3GAr3WU7IOW79QSu1yM6/AkZgcP8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}