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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '29dec77c1e770a3edd812c0d7853e1accd79bd7bf45ac635990b07607d25d649' 
  AND token = 'g5Khy3sDYamdrIVuuIR7r3B7g6KK4dBSjubY+xWVLjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}