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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d86b7187b0413e19fbdf21782a06b40f86e8fab63be7efb3cf39e14aacf3373' 
  AND token = 'poU5KCBezeMBx1UyTbSOR+ejgsdXOEyamdUNSJNV7HY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}