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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af79b466e6d2f2a88fe73f0e2694fbf02e49a33e1d75cf6ec98296c1581407ba' 
  AND token = 'Nu98xJAdsAN6VHNPiZLx9r/NMa1ynur9EWs7Bm1Eou4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}