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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6efb5362273ff6c7e01b4c541e54aee5c375a7d388eb5887d6209227baff89e6' 
  AND token = 'TDHzY8KRG+KMg8TwtCv26H8X5mGMq2dBWVa/o2Kbd88=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}