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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'affa07300208d8afa38ff0cea03ed548f5e69a82b3dd17db7d3a5a5b119d5b49' 
  AND token = 'SsRaLR11ey8hfIZFZoV+n3VLnRmbXWnQlsZ5NGuvsdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}