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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0f502c4ce7749ea0bb4f5a6762717da0ef92e9a155fbfefee2c12c025099f45' 
  AND token = 'UYkHuSoxJAfvKLdMxSXDvp48ILe+zpaLi46IiZjWjg4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}