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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21f976cb9bfefa8e194457bfe594f758a345e91a1e16d1358bc4429054e6134f' 
  AND token = 'yYg/eDSJECWc86lt66jVNP2+3xdcPClUC7wlGI0oHTc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}