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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d9f2031ec84ab4f52d4825eb24320e10e0d083ffc00e1f1a279ed82c1e1de05' 
  AND token = 'lEoD6/IS9Q9Jbe/BZ7x5lFdivHSiGZ+1+PnUIpc7BGU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}