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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c72df25a0e584cb2021b5f8370d12cd8da923ded1367c808eb853a275dd1e07' 
  AND token = 'JQS2WDEbti5/Hzjm+CUJEWRWlTr9T974l5SChzxtfTQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}