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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c80de32d40047a143d573e30c3d5aec3582c44aabebf55ec49a3eeaaf6cad6a' 
  AND token = 'prWA2+HYYnrBDu9brQE2/I2HRygBP42BF7vRnDmPUkQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}