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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c17c33716c4935a022315c2e4865777d1317badf7d60356cac1366fbd1cff7' 
  AND token = 'MTa87gcJa9g6x8tyFCkwXqwJ/87YTBph4KjOn8iWh80=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}