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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f5e2c6c5ecd7965a6bf6b435d052404a484a3220ca72c74293da46344e96ac8f' 
  AND token = 'Erm1gu6Qm8ASRmytSpT6bHyWwPL+cS+mUZMe7wcUqMo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}