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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ed67be4b00d7d0bd2fb7f64808590eb4f9499a2be834bc012324575b4f8a129' 
  AND token = 'mYHemok+F9bg1HLF4TNyMaC/Oc/aBuElCR4SfTnES+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}