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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5476c81e614d8fc27d1a57355de357f068d4b19392f78eea57705f1c62b0c9ee' 
  AND token = 'nwZ8Nkt+MrshGlW7ttCgzu3Xf4a6SGw/4D2p01wDBeY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}