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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f3bf42ae9bf726a0e6bc1b384c36870021009d2cabb3ed07c355e0db847d1a20' 
  AND token = 'MXFgt48mRPqSem5FaizyR8HkUUAeBR8O2FlSfcFwyNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}