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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48fbdd63d1bb4482cde2dfae25827a20c960cb38c39e7a8269fc42b85ba4bb00' 
  AND token = 'tD4kZRtaUv1RzEn0JmCWzCamDKUnXme/MFs1+ohaL0s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}