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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c31f7e48e8c92a5c02ed004a170826dda46d5809c3ebdc096cf285629ece395' 
  AND token = 'VBXHUxPRt0SD+QxtDJ3gF1R6EX9wKXGKdfkPm1Ltdhw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}