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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1456c72b4304efcf408fe97202796454914b72a68e575f8c1a4527b10fdeb261' 
  AND token = 'UKy5EPV7uRTvhbP5TYh4O6c/JOciNy+xa4Y1OiuR4uw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}