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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1001851eeb30515c74d507b45f0f8c2c1a69b124a29a71561da9dcd7d8f3ba9c' 
  AND token = 'fz1Bs8aWVRGbCrJ9NMZTPkiz+DWb0V86dGMiVkyt0YE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}